Pelleting Diets Impairs TRAMP Prostate Carcinogenesis
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چکیده
منابع مشابه
Chemoprevention of Prostate Carcinogenesis by a-Difluoromethylornithine in TRAMP Mice
Development of effective chemopreventive agents for human consumption requires conclusive evidence of their efficacy in animal models that have relevance to human diseases. Transgenic adenocarcinoma mouse prostate (TRAMP) is an excellent model of prostate cancer that mimics progressive forms of human disease inasmuch as 100% of males develop histological PIN by 8–12 weeks of age that progress t...
متن کاملChemoprevention of prostate carcinogenesis by alpha-difluoromethylornithine in TRAMP mice.
Development of effective chemopreventive agents for human consumption requires conclusive evidence of their efficacy in animal models that have relevance to human diseases. Transgenic adenocarcinoma mouse prostate (TRAMP) is an excellent model of prostate cancer that mimics progressive forms of human disease inasmuch as 100% of males develop histological PIN by 8-12 weeks of age that progress t...
متن کاملThe aryl hydrocarbon receptor inhibits prostate carcinogenesis in TRAMP mice.
The aryl hydrocarbon receptor (AhR) is a transcription factor that mediates the inhibitory effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on prostate growth and also modulates normal prostate development. This is evidenced by AhR null mice (Ahr-/-) having smaller dorsolateral and anterior prostates, even though all prostate lobes remain histologically normal. To test the hypothesis that ...
متن کاملMixed tocotrienols inhibit prostate carcinogenesis in TRAMP mice.
The biological activities of tocotrienols are receiving increasing attention. Herein, we report the efficacy of a mixed-tocotrienol diet against prostate tumorigenesis in the transgenic adenocarcinoma mouse prostate (TRAMP) mouse model. Male TRAMP mice, 8 wk old, were fed 0.1%, 0.3%, or 1% mixed tocotrienols in AIN-76A diet up to 24 wk old. Likewise, a positive control group consisting of male ...
متن کاملThe interactions of dietary tomato powder and soy germ on prostate carcinogenesis in the TRAMP model.
The interactions between bioactive-rich food components within a complex human diet for the inhibition of prostate carcinogenesis are largely unknown and difficult to quantify in humans. Tomato and soy products have each shown anti-prostate cancer (PCa) activity in laboratory studies. The objective of this study was to determine the efficacy of dietary tomato and soy germ, alone and in combinat...
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ژورنال
عنوان ژورنال: Food and Nutrition Sciences
سال: 2017
ISSN: 2157-944X,2157-9458
DOI: 10.4236/fns.2017.82014